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740 Y-P
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.
Catalog No. TQ0003Cas No. 1236188-16-1
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Purity:99.87%
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740 Y-P
Catalog No. TQ0003Alias 740YPDGFR, PDGFR 740Y-PCas No. 1236188-16-1
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $89 | In Stock | |
| 2 mg | $139 | In Stock | |
| 5 mg | $265 | In Stock | |
| 10 mg | $393 | In Stock | |
| 25 mg | $658 | In Stock | |
| 50 mg | $937 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. |
| In vitro | 740 Y-P is a synthetic biotinylated peptide. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%) and in the former instance, a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell-permeable SH2 domain-binding peptide [1]. 740Y-P is as effective as a growth factor (FGF2) at promoting neuronal cell survival via the established PI 3-kinase-Akt survival cascade. Stimulation of neuronal cell survival by the PDGFR740Y-P peptide is dose-dependent and does not require insulin[2]. |
| Alias | 740YPDGFR, PDGFR 740Y-P |
| Molecular Weight | 3270.7 |
| Formula | C141H222N43O39PS3 |
| Cas No. | 1236188-16-1 |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | H2O: < 1 mg/mL (Insoluble)  H2O: 5.5 mg/mL (1.68 mM), Adjust pH with HCl and sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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